– Nutritional ketosisis a very powerful tool. And it can be used to achieve metabolic state andwell-being in people who have illness associated with insulin resistance or inflaming. Now, there are lots ofmyths and breaches about ketogenic nutrition and about nutritional ketosis and I wanna really focus on the technical prove around safety and efficacy ofthis approach to nutrition. And I realize it’s hardfor parties to commit to this kind of endeavor if people around you are saying,
“Oh, this is dangerous soyou shouldn’t be doing it.” So you need to be confident that if you commence this that you’re doing it in asafe and efficacious acces. In study after study, not just ours but others, a well-formulated ketogenicdiet when compared to a standard calorie restricted low fat diet has a greater effect on weight loss and specially loss ofabdominal adipose tissue and it’s the adipose tissue ora fat mass within the abdomen that is the most dangerous fat that we carry in our body.For instance, a study thatI did with Dr. Jeff Volek and Dr. Cassandra Forsythe, one of his graduate student, we compared a high carbohydrate low-fat calorie limited dietto a ketogenic food that parties followed where their education was to eat to satiety, that is not count calories and don’t inhibit calories but munch enough to feel like they had had enough food and they weren’t hungry.
And we ranged the study for 12 weeks. And at the end of 12 weeks, the weight loss in the high carbohydratelow-fat group was about half the weight loss in theketogenic nutrition radical. Now, some critics willsay that well, when you go into ketogenic food, a lotof your weight loss is water. But we are genuinely did careful measurements of body fat and the sea loss on the ketogenic food was only about 1/5 of significant differences so five kilograms on the carbohydrate rich low-fat diet and 10 kilograms on the ketogenic nutrition and simply about 1/5 ofthat difference was ocean, the residue was torso fatty. More importantly, we usedthe dual x-ray absorptiometry so called DEXA procedure tomeasure torso fatten content. There is a significantly greater reduction in abdominal overweight, soit’s not just total fatty, it’s not overweight from under the skin, but it’s some of the most dangerous fatty is more rapidly mobilized when someone gets the ketogenic diet right. The next most common effect is for people who have either slightlyor markedly hoisted blood glucose levels positions, soeither prediabetes or diabetes, a spur response of the ketogenic nutrition is a reduction in blood glucose. Now, that offsets feel becauseif you dine less carbohydrate in a food, there’sgoing to be less glucose produced by digestion andthe level of sugar coming into the blood is gonna be reduced, that’s what we routinely see.
However, in Dr. Forsythes study … Now, these are people with prediabetes but their blood sugars arestill somewhat hoisted. We interpreted a marked reduction in blood glucose in the people on the ketogenic diet and no change in bloodglucose in the people who were on the highcarbohydrate low-fat diet. What’s more interestingis that we also weighed blood insulin positions. And insulin’s a hormone thatmakes glucose go into cells, so if the blood sugarcame down, you’d think that the body was acquiring more insulin to make it go into the cells. But it was the opposite of which is something we verified. And that is that insulinlevel came down dramatically, blood glucose came down. And the only way you canmake sense out of that is that the ketogenic dietimproved insulin sensitivity, that is the body’s responseto any one molecule of insulin is markedly greater.
And that’s a consistent finding we’ve seen across numerou studies and that’s the findings and conclusions thathas tell us to the concept that we can actuallyreverse the root cause of Type 2 diabetes. Another effect of awell-formulated ketogenic food is to change the blood lipid ethics that are characteristic of metabolic ailment. And, by the way, metabolic syndrome is too referred to as prediabetes. Normally we’d see with metabolic condition a reduced good cholesterol, an increase in triglycerides and a greater proportion of the small dense or bad LDL cholesterol.And when we looked at that in this cohort, we determined that triglycerides sunk. Now, they was downed in both groups but they went down more than twice as much in the patients on the ketogenic food. And by they way, theywere eating more overweight, and hitherto the blood paunch ranks lowered. HDL went up about 13% which is greater than anyHDL response we can get from any medications that we have available, that we can write as a drug. So this is a pretty much unique benefit to well-formulated ketogenic nutrition. And then the small dense LDL which are the most dangerous didn’t go down. If anything they wentdown somewhat in the group who were eating the high-pitched carb low-fat diet and was downed aggressively in the group on the ketogenic diet.So again, all the lipid changes are going in the right direction infavor of the ketogenic nutrition. So again, the concern about eating a high fatty food, snacking maybe eggs and meat and dairy which contains cholesterol, the actual, the cholesterol in the blood and the blood lipids arechanging all in a profitable nature when one gets this diet right.
If you’re eating low-pitched carbohydrate and moderate protein, the majority of your dietarycalories collected from fatty. And a good deal of the fatsthat parties eat frequently collected from animal concoctions or from dairy and cocoa butter and things, who the hell is saturated fatties. And so the question is iseating a lot of saturated fat hazardous when you’re on a ketogenic nutrition? And the reason peoplepropose it as dangerous is that we know that whenyou calibrate blood the different levels of saturated fat, thatthe higher the blood stage of saturated fat, thegreater the risk of diabetes, a heart attack and overall mortality.And so if you assume thateating saturated clears fixes the blood rank go up, that would suggest this is dangerous. But beings hadn’t everactually looked at what happens to the blood tiers with saturated overweight when they’re going toketogenic food, we are therefore did.
And which is something we observed was, even if they are, the people on the high fatty nutrition, the ketogenic food were devouring three times asmany grams of saturated solid per period, their bloodlevels of saturated fatty actually were lower than the group eating the lower saturatedfat uptake high-pitched carb diet. And again, this is a head scratcher.It appears that we’ve disconnected intake from blood elevations. And that violates the lawthat all dietitians tell you that you are what you eat. In actuality, you are whatyou save from what you eat. And the elegant thingabout the ketogenic diet is it teaches your torso toburn solid more efficiently. How effectively? Well, we did a study where we looked at highly trained athletessome of whom were following a traditional high-pitched carbohydrate loading nutrition regimen and the other half of them “ve been following” a well-formulated ketogenic diet.And these parties had beenfollowing these foods for at least six months or longer, which means that theywere fully keto-adapted for the ones on the low carbohydrate or ketogenic diet.
And when we looked at the resting charge of fatty oxidation, it was about double as much on the low carbohydrate ketogenic diet as it was on the high-pitched carbohydrate nutrition. So again, highly trainedathletes, theoretically, their bodies are highlyconditioned to burn overweight for gasoline during exercise and hitherto, exactly the difference of diet redoubled the bodies’ abilityto burn fatty for gasoline. And then as they … We had them do greater andgreater levels of exercise, the people on theketogenic diet demonstrated remarkable ability to use solid for fuel. The players like thatbecause they can run on body fat accumulates muchbetter than to eat and load with carbohydrate which means that when you’re keto-adapted, your mas has a capability ofgetting rid of saturated fatty and so the amount youeat is not important, it’s how much your bodysaves from what you eat. And clearly, the bodydoesn’t save saturated fat when you’re keto-adapted, which meant that saturated fats are not destructive when spent, if you’re keto-adapted.Another very importantarea of current study is in the topic of inflammation because we know that when we measure biomarkers of rash, and there have beensome that we’ve evaluated over the last century, like grey blood cell count and some that are morerecent adds-on to our ways of measuring inflammation.
That those levels predictthe later onset of sickness like myocardial infarction, Type 2 diabetes, Alzheimer’s disease and manyof the common forms of cancer. And so in doing the studywith Dr. Volek and Forsythe, we actually quantified everybiomarker we could think of and we was put forward by 14 differentbiomarkers of inflammation.And when we equated them for the people in the high-pitched carb dietversus parties adapted to the low-toned carb high fatty nutrition , nothing of the levels ofinflammation went down more in the people who were onthe high carb low fat diet. In contrast, 7 of those 14 were significantly reduced for the people on thewell-formulated ketogenic food. That is on average therewas a marked reduction in inflammation with theketogenic diet, indicating that this has a wide-rangingantiinflammatory outcome. Now, up until recently, that’s been what we scientists call a phenomenon. We see it’s happeningbut we don’t know why. And it turns out thatthere is a particular gene, it’s kind of like a traffic patrolman gene, it modulates the flow oftraffic around inflammation.
And this gene is targeteddirectly by the ketone that we have circulating…A primary ketone in our blood which is called -hydroxybutyrate, or BHB. And this is a place whereketones talk to your genes and your genes turn downthe heat, if you are able to, through a governed series of events to reduce inflammation of the body and that has the likelihood ofhaving very positive impact not just on reducing insulin resistance but too increasing other commonchronic diseases, as well. Now we not only know thatthe inflammation goes down, but we know why it goes downand why it is so effective and even modest levelsof ketones, the levels that you achieve merely byrestricting carbohydrates to less than 5% of total caloriesand impeding protein moderate.We’re doing a study withIndiana University Health where we banked over 260 parties with Type 2 diabetes and put them on awell-formulated ketogenic diet. This study will be going on for two years, but I want to show you just the early data from the first 10 weeks of the study.
All these parties had thediagnosis of Type 2 diabetes. Some were inadequately restricted, some were pretty well controlled, some were very tightly insured. So we fractioned the biomarkerof diabetes domination called hemoglobin A1c or HBA1c into high levels, intermediate degrees and well controlled ranks. And in all three cases, after 10 weeks, there was a reduction inthe level of hemoglobin A1c and this impact was greatest in the people who had the highest levels. So people who had the poorestcontrol of their diabetes got the greatest effect, butall three radicals have implications. And the result was that overhalf of these people moved from having hemoglobin A1clevels in the diabetes range into the non-diabetes range. What’s really intriguing is commonly in medical care diabetes, youget better glucose control by devoting beings more drugs.In this case, we tookaway most of the pharmaceuticals from five of the seven classesof diabetes remedies. And the two most dangerous which are insulin and sulfonylurea, those are the two grades of drugs that are most likely to cause hypoglycemia which is probably the most threatening side effect, short-term side effectof in diabetes administration that we either stopped or markedly abbreviated the majority of those medicines in these patients. And so here, again, “were having” the mystery, less drug, better verify.
And the reason we can get better control with less medication is -hydroxybutyrate in ketones, in general, speak to the genes andchange profoundly how the body capacities, including changing how the body responds to insulin so the bodycan get much greater benefit from far less insulin. And then as a side effect of this, again, we told parties to eat to satiety. It limited carbs, protein in moderation, so much better fatty as they needed, and again, they are unable kept butter on their meat, they are unable articulated butter ordressing on their veggies and trough with vegetables, things like that.And so they were eating to satiety, and yet 75% of these patients lost more than 5% of their body weight. And on average, the body weight loss was as a little bit over 7 %. And that was just in the first 10 weeks. At six months in this cohort, the weight loss went from 7% to 12%. So this is no longer a short-termquick loss and then regain, but it appears to be asustained long-term effect.
Because, again, people whoare six months into our study are doing the same thing wetold them to do at the onslaught and that is limit carbohydrate, protein in moderation, dine flab to satiety and thatgives the body permission to burn a lot of torso fatstores because the body has become so efficientin burning fat for fuel.Just to mention other conditions that we’ve seen that show improvementwith the ketogenic food, exactly general muscle andjoin aches and agonies. Grouchy bowel syndrometypically to do better. Polycystic ovary syndrome in females. Beings with migraine, headaches has indicated that either their frequency is down, the severity is down and somepeople get complete remission of their migraines when theyget the ketogenic nutrition right. As we pictured from thestudy of Dr. Forsythe, metabolic condition orprediabetes has improved along with that liver overweight stages go down which is a side effect ofpoorly held diabetes.
And we see improvements in fluid retention and blood pressure, as well. This is a very powerful tool. It can have very beneficial effects on a number of chronic conditions, but when a person’s taking medicines for these chronic conditions, those beneficial effects typically mandate a sharp and rapid reduction in medication. And that can be dangerous, unless you have the assistance of a physician whounderstands this type of diet and understands how tomanage the medications.This cannot be be done in order to a informal action, you can’t start a food and goback and see your physician six days later and say, “Sowhat do you think I should do with my diabetes medication? ” Because frequently wehave most of the changes in the first six daylights whenpeople get the diet right. The concern is finding adoctor who understands this and that is sometimes difficult, but we see increasinginterest in specialists, so if you ogle carefully, you can probably find someone who can help you, if youneed that kind of assistance when you’re followingthis type of regimen. So again, for our opinion is a well developed diet is not only safe but it can be very effectivein reversing disease. These consequences are so strong. However, this has to be startedwith careful monitoring. Stated in this directly, you have to find a physician who can help you manage your medications in the proper way that thisbe done where the potential benefits far outweigh any potential risks involving changes in medication use.