Category Archives: testosterone

Lipids Part 2: Steroids

Lipids Part 2: Steroids

 

Hey it’s professor Dave, I’m going totell you about steroids. When people discover the word steroids, they typically think of anabolic steroids, which are synthetic derivatives of testosterone, but in actuality, steroids can be attributed to a class of molecules that includes not just hormones, but also certain vitamins and cholesterol. Let’s learn a bit about the structure and function of steroids.

Steroids are all derivatives of this reverberate system, which is comprised of fourrings. The A, B, and C resounds are six membered doughnuts while the D ring is an afive-membered ring. There are also always methyl groups on these two carbons, andfor affluence of communications we will always figure this doughnut organisation the following way: This is carbon 1, and crowds 1-10 will wrap around hoops A and B this road. Then carbon 11 prances over to reverberate C and we wrap around rings C and D, lastly numbering these two methyl groups likethis.All the steroids we examine will be based on this structure.

Now we know thatsix-membered hoops like to be in chair conformations, so let’s see what thatwould actually look like. First we should note that there are two common conformations for the A reverberate either with a trans echoing junctionbetween A and B like this, or a cis seam putting hoop A like this. Too noting that the methyls are in theaxial position pointing upwards, and we will usually refer to the substituents on the same side as those methyls as beta substituents, whereas ones on theother side, trans to the methyls, will be alpha substituents.The orientation of aring is highly dependent on the hydrogen on carbon 5. If that hydrogen is alpha, or onthe hasten alliance you get the trans AB junction.

If the hydrogen is beta, or onthe wedge ligament, you get the cis AB junction. Now, where else do steroids varyin design? A common locating for a substituent is carbon 17. Different alkyl groups at this spot are creating different steroids, one of which is cholesterol. Cholesterol has eight stereocenters which necessitate 256 different stereoisomers of this structure are possible, but only this specific one is cholesterol. This is an intermediate in the biosynthesis of all the steroids we need in our torso, and although we often consume cholesterol, we don’t need to because we too make it ourselves, so wewill typically have more cholesterol than we need, and too much cholesterol inthe diet leads to blockage arteries and feeling problems.Let’s look at another type of steroid, the gender hormones.

These can be divided into three first-class: the female hormonesor estrogens, the male hormones or androgens, and gestation hormones orprogestin. Let’s look at the female hormones firstly. These are estrone andestradiol, liter which differ only in the level of oxidation at carbon 17. Estradiol issecreted by the ovaries and knocks off the changes that occur during puberty, and likewise makes developed at the mammary glands during pregnancy, whereas estrone is just a metabolized form of estradiol that is excreted.The male sex hormones, and androsterone and testosterone, are incredibly similar to the female hormones, with the only differences being carried out in the A reverberate.

Similar to the female hormones, testosterone does all the work, promoting the growth of body hair and facial whisker, lowering of the spokesperson and other characters associated with puberty, whereas androsterone is just the metabolized version that is ejected into the urine.And progesterone is the most important pregnancy hormone, which plans the uterine rowing for implantation of a fertilized egg and checks further ovulation during pregnancy. Other hormones like cortisol and cortisol regulate many other biological tasks, like metabolism and controlling inflammation. And that folds our canvas of lipids. Thanks for watching, chaps. Subscribe to my channel for more tutorials, and as always, feel free to email me :.

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Why Do Men’s Testosterone Levels Fluctuate As They Age

 

So testosterone status will fluctuate with aging with overall a gradual slump and the trouble with testosterone stages ordinary is anywhere from 300 to 1200 so when you’re 300 or less it’s absolutely low-spirited but ailments like obesity diabetes cigarette smoking even feeling thyroid diseases can all cause waverings at any given age the one problem with testosterone is you don’t want to be quick to change without looking

for other conditions that can cause it because the stas drone can cause prostate growth can cause breast growth and men and if there’s especially a family history of prostate cancer it can increase the likelihood of prostate cancer in a person so formerly you look to for carbohydrate for blood pressure for cholesterol for thyroid and you guideline all those things out if a person has an utterly low-grade testosterone position in the specify of manifestations of lethargy listlessness no force maybe some depression that would be the low tea condition

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October 2020 AJP Editor Spotlight: Low-Dose Testosterone for Depression in Women

[ Music] many years of research relate sketches in hormones to gamble for many mental disturbance and one of the particularly strong areas of research perceives a link between low-grade testosterone and the risk for major depressive disorder in a significant brand-new randomized self-controlled inquiry dicta and colleagues examine the degree to which testosterone administration might actually be useful in the treatment of major dimple and its most important observes to come out of this new randomized ascendancy trial are to suggest that testosterone may in fact not be helpful in the treatment of depression and this supports why it’s important to move beyond observational exploring ways to experimentations that examine the efficacy of a care for clinicians this should promote a certain level of caution about applying a medication like testosterone rehabilitation in the hopes of reducing depressive evidences[ Music ].

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